Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Macrophage retrotransposon expression is associated with lupus.

Genes and immunity·2025
Same author

Phosphopeptides P140 cause oxidative burst responses of pulmonary macrophages in an imiquimod-induced lupus model.

Molecular biomedicine·2023
Same author

Effects of mobile APP for immunization on vaccination compliance of migrant children in southwest China: A community trial study.

Human vaccines & immunotherapeutics·2022
Same author

Noninvasive imaging of the lung NETosis by anti-Ly6G iron oxide nanoparticles.

Heliyon·2022
Same author

Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance.

Cellular and molecular life sciences : CMLS·2022
Same author

Neutrophil-derived reactive oxygen species promote tumor colonization.

Communications biology·2021
Same journal

Direct Androgen Receptor Antagonism Enhances Therapeutic PSMA Radioligand Uptake in Prostate Cancer Models.

Molecular imaging and biology·2026
Same journal

Advances in PD-L1 Targeted Molecular Imaging Radiotracers Research: From Preclinical Exploration to Clinical Application.

Molecular imaging and biology·2026
Same journal

Preclinical Evaluation of [<sup>18</sup>F]JNJ-1: A Novel Positron Emission Tomography Ligand Targeting AMPAR/TARP γ8.

Molecular imaging and biology·2026
Same journal

Probing Early Myocardial Remodeling in Response to a High-Fat Diet in Mice by Evaluation of Extracellular Volume Fraction Using 4D Retrospectively Gated Micro-CT Imaging.

Molecular imaging and biology·2026
Same journal

Molecular Imaging of Butyrylcholinesterase Associated with Amyloid-β Plaques Distinguishes 5XFAD from Wild-Type Mice: A Proof-of-Concept.

Molecular imaging and biology·2026
Same journal

Brain Amyloid Deposition Is Negatively Associated with Cardiac Amyloid Retention in Apo E4 Carriers: A Pilot Study.

Molecular imaging and biology·2026
See all related articles

Related Experiment Video

Updated: May 30, 2026

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
06:28

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

Fast-specific tomography imaging via Cerenkov emission.

Jianghong Zhong1, Chenghu Qin, Xin Yang

  • 1Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Room 931, Automation Building, No.95 Zhongguancun East Road, Beijing, 100190, China.

Molecular Imaging and Biology
|July 26, 2011
PubMed
Summary
This summary is machine-generated.

This study introduces a novel imaging technique combining Cerenkov luminescence and X-ray computed tomography for precise tumor visualization. The method accurately maps radiopharmaceutical distribution, aiding in oncology research and diagnostics.

More Related Videos

Cerenkov Luminescence Imaging (CLI) for Cancer Therapy Monitoring
08:45

Cerenkov Luminescence Imaging (CLI) for Cancer Therapy Monitoring

Published on: November 13, 2012

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

Related Experiment Videos

Last Updated: May 30, 2026

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
06:28

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

Cerenkov Luminescence Imaging (CLI) for Cancer Therapy Monitoring
08:45

Cerenkov Luminescence Imaging (CLI) for Cancer Therapy Monitoring

Published on: November 13, 2012

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

Area of Science:

  • Medical Imaging
  • Biophysics
  • Oncology

Background:

  • Positron emission tomography (PET) with fluoro-18-deoxyglucose (FDG) visualizes radioisotope distribution but requires complementary methods for enhanced specificity.
  • Understanding tumor-specific radiopharmaceutical uptake necessitates advanced data modeling and imaging techniques.

Purpose of the Study:

  • To develop and validate an in vivo imaging methodology for precisely localizing radiopharmaceutical mobility and organ uptake.
  • To integrate Cerenkov luminescence imaging with X-ray computed tomography for improved tumor visualization.

Main Methods:

  • Multi-view imaging acquisition in small animals using 2-deoxy-2-[(18)F]fluoro-D-glucose.
  • Fusion processing of X-ray computed tomography (CT) and Cerenkov luminescence imaging (CLI) data.
  • Generation of in vivo Cerenkov luminescence tomography (CLT) images using geometric row scaling, L(1/2) regularization, and the SP(3) forward model.

Main Results:

  • Successful generation of in vivo Cerenkov luminescence tomography images.
  • Confirmation of tumor-specific tomography by comparing Cerenkov emission with in vitro radioactivity measurements.
  • Demonstration of the technique's ability to localize radionuclide mobility and organ uptake.

Conclusions:

  • The developed technique offers a rapid and effective method for localizing radiopharmaceutical distribution in vivo.
  • This imaging methodology provides valuable insights for oncology research and clinical applications.
  • The integration of CT and CLI enhances the understanding of radiotracer behavior in biological systems.