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In vitro activity of ceftobiprole and seven other antimicrobial agents against invasive Streptococcus pneumoniae

E Ríos Dueñas1, I Rodríguez-Avial, J J Picazo

  • 1Servicio de Microbiología, Hospital Clínico San Carlos, Plaza de Cristo Rey s/n, 28040 Madrid, Spain. bioesther@hotmail.com

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|July 26, 2011
PubMed

Insights

Ceftobiprole demonstrated superior in vitro activity against invasive Streptococcus pneumoniae compared to penicillin and cefotaxime. This finding suggests ceftobiprole

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Invasive Streptococcus pneumoniae infections pose a significant public health challenge.
  • Antimicrobial resistance in S. pneumoniae necessitates the evaluation of novel therapeutic agents.
  • Understanding serotype distribution and resistance patterns is crucial for effective treatment strategies.

Purpose of the Study:

  • To compare the in vitro activity of ceftobiprole with other antimicrobial agents against invasive S. pneumoniae.
  • To characterize erythromycin-resistant strains and evaluate the serotype distribution of pneumococcal isolates.
  • To assess the potential of ceftobiprole as a treatment option for pneumococcal infections.

Main Methods:

  • In vitro antimicrobial susceptibility testing using broth microdilution (CLSI guidelines).
  • Serotyping of S. pneumoniae isolates by Quellung reaction.
  • Detection of macrolide resistance genes [erm(B) and mef(A/E)] by PCR.

Main Results:

  • Ceftobiprole exhibited potent in vitro activity against all 70 invasive S. pneumoniae isolates, with MIC(50)/MIC(90) values of 0.03/1 mg/L.
  • Eighty-seven percent of the 25 detected serotypes were non-PCV7 types.
  • Resistance rates were 20% for erythromycin, 8.6% for clindamycin, and 16% for tetracycline.

Conclusions:

  • Ceftobiprole displayed significantly higher in vitro activity than penicillin and cefotaxime against invasive S. pneumoniae.
  • The promising in vitro profile suggests ceftobiprole is a potential candidate for treating pneumococcal infections.
  • Continued surveillance of antimicrobial resistance and serotype prevalence is essential.

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