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Updated: May 30, 2026
07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
[Biological therapy in pediatric rheumatology]
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
|July 27, 2011
Summary
Biological therapies significantly improve outcomes for children with juvenile rheumatoid arthritis. Gene-engineered drugs achieve remission in 70% of patients, enhancing quality of life and long-term prognosis.
Area of Science:
- Pediatric Rheumatology
- Immunology
- Pharmacology
Context:
- Juvenile rheumatoid arthritis (JRA) is a chronic autoimmune disease affecting children.
- Traditional immunosuppressants have limitations in managing JRA.
- The Research Centre of Children's Health has extensive experience in treating pediatric JRA.
Purpose:
- To present the experience of treating 438 children with JRA using various biologic agents.
- To evaluate the efficacy and impact of differential biologic therapy compared to classical immunosuppressants.
- To assess the effect of gene-engineered drugs on disease activity, remission rates, and patient quality of life.
Summary:
- The study involved 438 children treated with biologic preparations: infliximab, adalimumab, etanercept, rituximab, and tocilizumab.
- Differential biologic therapy achieved clinico-laboratory remission in 70% and reduced disease activity in 20% of patients within one year.
- This approach contrasts with classical immunosuppressants, showing superior outcomes.
Impact:
- Biologic therapy significantly improves the quality of life for children with JRA and their families.
- Gene-engineered drugs promote normal growth and development in pediatric patients.
- These treatments positively affect the prognosis of JRA, a previously incurable condition.
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