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Updated: May 30, 2026

Cholesterol Efflux Assay
Published on: March 6, 2012
Structural and biophysical insight into cholesteryl ester-transfer protein
1Pfizer Research and Development, Eastern Point Road, Groton, CT 06430, USA.
Abstract:
CETP (cholesteryl ester-transfer protein) is essential for neutral lipid transfer between HDL (high-density lipoprotein) and LDL (low-density lipoprotein) and plays a critical role in the reverse cholesterol transfer pathway. In clinical trials, CETP inhibitors increase HDL levels and reduce LDL levels, and therefore may be used as a potential treatment for atherosclerosis. In this review, we cover the analysis of CETP structure and provide insights into CETP-mediated lipid transfer based on a collection of structural and biophysical data.
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