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Updated: May 30, 2026
09:24
Functional Assessment of Intestinal Permeability and Neutrophil Transepithelial Migration in Mice using a Standardized Intestinal Loop Model
Published on: February 11, 2021
Intestinal inflammation and the enterocyte transportome
Isabel Romero-Calvo1, Cristina Mascaraque, Antonio Zarzuelo
1Department of Biochemistry and Molecular Biology II, CIBERehd, School of Pharmacy, University of Granada, Granada, Spain.
Biochemical Society Transactions
|July 27, 2011
Summary
Diarrhoea in chronic colitis involves inhibited secretory and absorptive processes. This review examines changes in the intestinal transportome during chronic inflammation.
Area of Science:
- Gastroenterology
- Cellular Biology
- Physiology
Background:
- Diarrhoea is a key symptom of intestinal inflammation.
- Acute intestinal inflammation mechanisms are understood, involving mediators and epithelial changes.
- Chronic colitis mechanisms, particularly ionic transport, are less clear.
Purpose of the Study:
- To review existing evidence on the transportome in chronic intestinal inflammation.
- To elucidate the mechanisms behind altered ionic transport in chronic colitis.
- To understand the role of the transportome in protracted intestinal inflammation.
Main Methods:
- Literature review of studies on chronic intestinal inflammation.
- Analysis of evidence regarding epithelial transport processes.
- Examination of the 'transportome' in the context of colitis.
Main Results:
- Chronic colitis is characterized by inhibited secretory and absorptive processes.
- Disturbances in ionic transport may be adaptive responses to prolonged inflammation.
- Changes in transportome expression, epithelial alterations, or damage contribute to these disturbances.
Conclusions:
- The transportome plays a critical role in the pathophysiology of chronic intestinal inflammation.
- Understanding transportome alterations is key to addressing diarrhoea in chronic colitis.
- Further research is needed to fully characterize transportome modulation in colitis.
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