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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
13:36

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

MicroRNAs in systemic rheumatic diseases.

Angela Ceribelli1, Bing Yao, Paul R Dominguez-Gutierrez

  • 1Department of Oral Biology, University of Florida, 1395 Center Drive, Gainesville, Florida 32610-0424, USA.

Arthritis Research & Therapy
|July 27, 2011
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are key regulators of gene expression implicated in autoimmune diseases like lupus and rheumatoid arthritis. Their altered levels serve as potential biomarkers for disease progression and therapeutic targets.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Immunology

Background:

  • MicroRNAs (miRNAs) are small, non-coding RNA molecules regulating gene expression.
  • miRNAs play crucial roles in physiological and pathological processes, including autoimmune diseases.
  • Abnormal miRNA expression is observed in systemic lupus erythematosus and rheumatoid arthritis.

Purpose of the Study:

  • To explore the role of miRNAs in the pathogenesis and progression of systemic rheumatic diseases.
  • To evaluate miRNAs as potential biomarkers for disease activity and treatment monitoring.
  • To investigate miRNAs as therapeutic targets for autoimmune disorders.

Main Methods:

  • Analysis of miRNA expression patterns in autoimmune diseases.
  • Correlation of miRNA levels with disease activity and clinical manifestations.
  • Review of current literature on miRNA involvement in rheumatic diseases.

Main Results:

  • miRNA dysregulation is linked to the pathogenesis of autoimmune diseases.
  • Specific miRNAs correlate with disease activity, such as renal flares in lupus.
  • miRNAs are promising biomarkers for diagnosis, prognosis, and treatment monitoring.

Conclusions:

  • miRNAs significantly influence the mechanisms underlying autoimmune disease development, relapse, and organ involvement.
  • Targeting specific miRNAs offers a potential therapeutic strategy for autoimmune disorders.
  • Further research aims to identify and manipulate miRNA targets for effective treatment.