Brain noradrenaline changes in rats prenatally exposed to ozone

In the present study we considered the possible impairment of developmental noradrenergic maturity of the cerebellum, cerebral cortex and pons at 10-, 20- and 30-day-old rats arising from mothers subjected to 1ppm ozone concentration during pregnancy. The noradrenaline concentration was found to be significantly reduced in the cerebellum during the study, while in the cerebral cortex and the pons it was found to be reduced at days 10 and 30 respectively as compared to controls. We concluded that prenatal exposure of 1.0ppm ozone causes embryonic/fetal changes manifested in postnatal levels of noradrenaline concentrations in the brains of rats.