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Related Concept Videos

Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
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The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
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Related Experiment Video

Updated: May 30, 2026

The Slice Culture Method for Following Development of Tooth Germs In Explant Culture
07:47

The Slice Culture Method for Following Development of Tooth Germs In Explant Culture

Published on: November 13, 2013

p63 in tooth development.

Alessandro Rufini1, Alberto Barlattani, Raffaella Docimo

  • 1Toxicology Unit, Medical Research Council, Leicester LE1 9HN, United Kingdom. ar230@le.ac.uk

Biochemical Pharmacology
|July 27, 2011
PubMed
Summary
This summary is machine-generated.

The p63 protein is crucial for tooth development, with its truncated isoforms, known as delta Np63 (ΔNp63), primarily driving this process. These isoforms are essential for maintaining the molecular signaling required for proper tooth formation.

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Last Updated: May 30, 2026

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Area of Science:

  • Developmental biology
  • Molecular genetics
  • Craniofacial development

Background:

  • Tooth development is a complex process involving intricate molecular signaling pathways.
  • The p53 family member, p63, plays a critical role in tooth formation, as evidenced by developmental defects in its absence.
  • p63 exists in various isoforms, including full-length TAp63 and truncated ΔNp63, generated through alternative promoters and splicing.

Purpose of the Study:

  • To review the experimental evidence highlighting the involvement of ΔNp63 isoforms in tooth development.
  • To elucidate the mechanism by which ΔNp63 sustains molecular signaling essential for tooth formation.

Main Methods:

  • Review of existing experimental data and literature on p63 and tooth development.
  • Analysis of genetic models (p63-deficient mice) and human genetic studies involving p63 mutations.
  • Examination of molecular pathways regulated by ΔNp63 in epithelial-mesenchymal interactions during odontogenesis.

Main Results:

  • Mice lacking p63 exhibit a complete absence of teeth.
  • Human mutations in p63 lead to syndromes affecting tooth morphology and number.
  • Tooth development is primarily dependent on the activity of N-terminally truncated ΔNp63 isoforms.
  • ΔNp63 isoforms are key in sustaining the molecular signaling orchestrating epithelial-mesenchymal interactions during tooth development.

Conclusions:

  • The truncated ΔNp63 isoforms are essential regulators of tooth development.
  • ΔNp63's role in maintaining epithelial-mesenchymal signaling is critical for successful odontogenesis.
  • Understanding ΔNp63 function provides insights into developmental defects affecting teeth.