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Updated: May 30, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Giant cell arteritis--an incidental finding.

Gillian A Greenhill¹, D W G Kennedy, A Evans

¹Department of Oral and Maxillofacial Surgery, Ninewells Hospital, Dundee DD1 9SY, Scotland, UK. gilliangreenhill@nhs.net

The British Journal of Oral & Maxillofacial Surgery

|July 27, 2011

Summary

Giant cell arteritis, a serious vascular condition, was incidentally diagnosed during basal cell carcinoma removal. This rare head and neck case highlights the importance of histopathological examination for early detection.

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Last Updated: May 30, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Area of Science:

Rheumatology
Dermatology
Vascular Medicine

Background:

Giant cell arteritis (GCA) is a systemic vasculitis requiring prompt diagnosis to prevent vision loss.
GCA presents with diverse local (headache, jaw claudication) and systemic (fever, malaise) symptoms.
Early management of GCA is crucial to mitigate severe complications like blindness.

Observation:

A basal cell carcinoma excision from the scalp led to an unexpected histological diagnosis of GCA.
This represents a unique instance of GCA identified incidentally in the head and neck region.
A literature review found no prior reports of similar incidental GCA diagnoses in this anatomical area.

Findings:

Histopathological examination revealed GCA as an incidental finding.
The diagnosis was made post-operatively after routine analysis of excised scalp tissue.
This case is novel, with no similar documented instances in head and neck pathology.

Implications:

Highlights the potential for incidental diagnoses of systemic diseases during routine procedures.
Underscores the value of thorough histopathological evaluation, even in seemingly straightforward cases.
Suggests that GCA may present asymptomatically or be overlooked in routine head and neck examinations.