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Updated: May 30, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
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A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization

Zohreh Khavandgar1, Christophe Poirier, Christopher J Clarke

  • 1Faculty of Dentistry, McGill University, Montreal, Quebec QC H3A 1A4, Canada.

The Journal of Cell Biology
|July 27, 2011
PubMed
Summary

The sphingomyelin phosphodiesterase 3 (Smpd3) gene mutation causes skeletal dysplasia. Osteoblast-specific Smpd3 expression corrects bone defects, indicating a cell-autonomous role in skeletal development.

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