Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Changes in the Appendicular Skeleton with Age

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

Longitudinal Research

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...

Longitudinal Studies

Longitudinal Studies

Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...

Role of Vitamins in Maintaining Bone Health

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Joint Associations of Prenatal Per- and Polyfluoroalkyl Substances and Metal Mixtures with Adiposity in Childhood and Adolescence.

Environmental science & technology·2026

Same author

Streetview greenspace types and dementia risk in older adults: The Multi-Ethnic Study of Atherosclerosis.

American journal of epidemiology·2026

Same author

Leveraging Artificial Intelligence in Allergy, Asthma, and Immunology With Environmental Exposures.

Allergy·2026

Same author

Association of Short-Term Pollen Exposure With Lung Function in COPD Patients.

Chronic obstructive pulmonary diseases (Miami, Fla.)·2026

Same author

Measurement error-robust causal inference via constructed instrumental variables.

Biometrics·2026

Same author

Author Correction: National analysis of cancer mortality and proximity to nuclear power plants in the United States.

Nature communications·2026

Same journal

Organizational Stressors, Burnout, and Mental Health Outcomes Among Local Government Employees During Disaster Response.

Journal of occupational and environmental medicine·2026

Same journal

What's new in HIV Exposure Management in 2026.

Journal of occupational and environmental medicine·2026

Same journal

Self-Reported Occupational Tuberculosis Exposure Among Healthcare Workers During COVID-19-Related Health System Reprioritisation in South Africa: A Cross-Sectional Study.

Journal of occupational and environmental medicine·2026

Same journal

Association Between Cigarette Smoking and Sleep Outcomes Among Long-Haul Truck Drivers: A Secondary Data Analysis.

Journal of occupational and environmental medicine·2026

Same journal

Work Exposome estimation through Job Exposure Matrices - JEMs?

Journal of occupational and environmental medicine·2026

Same journal

Occupational Exposure and Health Symptoms Related to the Tijuana River Valley Sewage Crisis - Results from an Assessment of Chemical Exposures, California, 2024.

Journal of occupational and environmental medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 30, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Longitudinal changes in bone lead levels: the VA Normative Aging Study.

Elissa Wilker¹, Susan Korrick, Linda H Nie

¹Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. ewilker@bidmc.harvard.edu

Journal of Occupational and Environmental Medicine

|July 27, 2011

Summary

This summary is machine-generated.

Bone lead levels in elderly men decline slowly over time, with tibia lead decreasing annually and patella lead showing an initial rapid decline. This suggests a longer bone lead half-life than previously understood.

More Related Videos

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Related Experiment Videos

Last Updated: May 30, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Area of Science:

Environmental Health
Toxicology
Gerontology

Background:

Bone lead serves as a cumulative biomarker for long-term lead exposure.
Lead stored in bone can be remobilized into circulation over time.
Understanding long-term bone lead dynamics is crucial for assessing chronic lead toxicity risks.

Purpose of the Study:

To analyze longitudinal changes in bone lead concentrations over an 11-year period.
To identify predictors of tibia and patella lead stores in elderly males.
To characterize the long-term kinetics of bone lead in a human population.

Main Methods:

Repeated bone lead measurements were collected from participants over 11 years.
K-x-ray fluorescence (KXRF) was utilized for bone lead quantification.
Mixed-effects models with random effects were employed to assess temporal changes.

Main Results:

A total of 554 elderly males contributed up to four bone lead measurements.
Tibia lead exhibited a statistically significant annual decline of -1.4% (95% CI: -2.2 to -0.7).
Patella lead showed an initial rapid decline of 5.1% per year for 4.6 years, followed by no significant change.

Conclusions:

The observed slow decline in bone lead suggests a longer biological half-life than previously estimated.
These findings have implications for understanding the persistence of lead exposure effects.
Further research is warranted to refine bone lead half-life estimates in aging populations.