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Induction of Endothelial Differentiation in Cardiac Progenitor Cells Under Low Serum Conditions
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Published on: January 7, 2019

Mobilization of stem and progenitor cells in cardiovascular diseases

W Wojakowski1, U Landmesser, R Bachowski

  • 1Third Division of Cardiology, Medical University of Silesia, Katowice, Poland. wojtek.wojakowski@gmail.com

Leukemia
|July 27, 2011
PubMed

Insights

Mobilized stem and progenitor cells (SPCs) from bone marrow aid vascular and heart repair after injury. Their function is impaired by cardiovascular risk factors but may predict outcomes in certain patients.

Area of Science:

  • Cardiovascular Research
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Bone marrow-derived stem and progenitor cells (SPCs) are crucial for repairing vascular endothelium and heart muscle after acute coronary syndromes.
  • Acute myocardial infarction triggers inflammation, mobilizing SPCs and increasing local chemoattractants, while neural and humoral signals promote their release from bone marrow.
  • Various circulating SPC types exist, but their exact roles in myocardial and endothelial repair remain unclear.

Purpose of the Study:

  • To review the mobilization of SPCs in acute ischemia and stable cardiovascular disease.
  • To highlight the potential of SPCs as cardiovascular risk markers.
  • To discuss factors influencing SPC mobilization and function.

Main Methods:

  • Literature review of studies on stem and progenitor cell mobilization.
  • Analysis of the role of SPCs in myocardial infarction and stroke.
  • Examination of factors affecting SPC number and function, including cardiovascular risk factors, exercise, and statins.

Main Results:

  • The number and function of circulating SPCs are reduced in patients with diabetes and other cardiovascular risk factors.
  • Physical exercise and statin use can improve SPC function.
  • Mobilization of SPCs in acute coronary syndromes and stable coronary artery disease may predict clinical outcomes.

Conclusions:

  • SPCs play a role in cardiovascular repair, but their contribution requires further elucidation.
  • Factors like coexisting diseases, age, and medications influence SPC mobilization and must be considered.
  • Circulating SPCs hold potential as biomarkers for cardiovascular risk assessment.

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