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[Effects of clonazepam taken per os by children with rebellious epileptic encephalopathies]
Insights
Clonazepam effectively treats severe childhood epilepsy, showing significant clinical and electrical improvements in 70% of cases. This anticonvulsant medication offers sustained benefits, even in drug-resistant epilepsy cases.
Area of Science:
- Neurology
- Pediatric Epilepsy
Background:
- Evolutive epileptic encephalopathies present severe clinical and electrical manifestations in children.
- Standard anti-epileptic poly-chemotherapies are often insufficient for these refractory cases.
Purpose of the Study:
- To evaluate the efficacy of clonazepam as an add-on therapy for children with severe epileptic encephalopathies.
- To assess the long-term effectiveness and safety of clonazepam in this patient population.
Main Methods:
- A study involving fourteen children with evolutive epileptic encephalopathies.
- Administration of clonazepam per-os in progressive doses, alongside existing anti-epileptic treatments.
Main Results:
- Clonazepam demonstrated significant efficacy, achieving visible amelioration in 70% of the studied children.
- Sustained clinical and electrical improvements were observed in patients treated for over a year, indicating long-lasting effects.
- When combined with other benzodiazepines, clonazepam showed a low incidence of side-effects and no cross-resistance in rebellious epilepsy cases.
Conclusions:
- Clonazepam is an effective adjunctive treatment for severe, drug-resistant childhood epilepsies.
- The medication provides sustained therapeutic benefits and is well-tolerated, even in combination therapies.
Abstract:
The effect of clonazepam, taken per-os and in very progressive doses, has been studied by the authors on fourteen children afflicted with evolutive epileptic encephalopathies and still presenting, in spite of heavy anti-epileptic polychemio-therapies, alarming clinical and electrical manifestations. Clonazepam proved to be an efficient contributive factor in the course of a curing process since, in 70% of the cases, it produced quite a visible amelioration. Its efficient action seems to last longer than that of other diazepines since half of their patients have now been treated with it for more than a year with, as a result, a constant clinical and electrical amelioration. As a last point, it appears to be a very useful drug when dealing with type of rebellious epilepsies since, when combined with other benzodiazepines, seldom side-effects and no "crossed resistances" can be observed.