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Related Concept Videos

The Micturition Reflex01:26

The Micturition Reflex

Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating urine...
Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
Urinary Bladder01:23

Urinary Bladder

The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
Urodynamic Studies: Uroflowmetry01:19

Urodynamic Studies: Uroflowmetry

Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Microbiota of the Urogenital Tract01:28

Microbiota of the Urogenital Tract

The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...

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Updated: May 30, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Overactive bladder in males.

Roger R Dmochowski1, Alex Gomelsky

  • 1Professor, Department of Urologic Surgery, Vanderbilt University Medical Center, A-1392, Medical Center North, Nashville, TN 37232, USA.

Therapeutic Advances in Urology
|July 27, 2011
PubMed
Summary
This summary is machine-generated.

Overactive bladder (OAB) affects many men, often undertreated with therapies for bladder outlet obstruction (BOO). This review explores OAB pathophysiology, evaluation, and current/emerging treatments for men.

Keywords:
anticholinergicbenign prostatic hypertrophyoveractive bladder

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Detrusor Underactivity Model in Rats by Conus Medullaris Transection
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Last Updated: May 30, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Area of Science:

  • Urology
  • Andrology
  • Pharmacology

Background:

  • Overactive bladder (OAB) symptoms significantly impact quality of life (QOL) in both genders.
  • OAB prevalence is similar in men and women, yet male OAB is frequently undertreated or misdiagnosed.
  • Current male OAB treatments often target bladder outlet obstruction (BOO) rather than OAB directly.

Purpose of the Study:

  • To review the pathophysiology and evaluation of OAB in men, particularly with benign prostatic hypertrophy (BPH) and BOO.
  • To assess the efficacy and safety of current medical therapies for male lower urinary tract symptoms (LUTS).
  • To discuss novel therapeutic strategies for male OAB.

Main Methods:

  • Literature review focusing on OAB pathophysiology, diagnosis, and treatment in men.
  • Analysis of existing data on medical therapies including alpha-adrenergic blockers, 5-alpha reductase inhibitors, and antimuscarinics.
  • Exploration of emerging treatment targets and strategies for male OAB.

Main Results:

  • OAB pathophysiology in men is complex, often intertwined with BPH and BOO.
  • Established medical therapies (alpha-blockers, 5-ARIs, antimuscarinics) show variable efficacy and safety profiles for male LUTS/OAB.
  • Limited specific treatments exist for male OAB, highlighting a gap in current management.

Conclusions:

  • Effective management of male OAB requires understanding its unique pathophysiology and differentiating it from BOO.
  • Current therapies offer partial solutions, necessitating further research into targeted treatments.
  • Future strategies may involve novel agents and a more personalized approach to male OAB treatment.