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The Micturition Reflex01:26

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Urinary Bladder01:23

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Updated: May 30, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

The overactive bladder.

Richard Foon1, Marcus J Drake

  • 1Urogynaecology Fellow, Bristol Urological Institute, Southmead Hospital, Bristol BS10 5NB, UK.

Therapeutic Advances in Urology
|July 27, 2011
PubMed
Summary
This summary is machine-generated.

Overactive bladder (OAB) significantly impacts quality of life, with current treatments ranging from lifestyle changes to surgery. Understanding complex pathophysiological mechanisms is key to developing more effective OAB therapies.

Keywords:
detrusor overactivityoveractive bladderurge incontinenceurgency

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Last Updated: May 30, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Real-Time Void Spot Assay
06:39

Real-Time Void Spot Assay

Published on: February 10, 2023

Area of Science:

  • Urology
  • Neuroscience
  • Pharmacology

Background:

  • Overactive bladder (OAB) is a common condition characterized by urinary urgency and associated symptoms, negatively affecting patients' quality of life.
  • Current OAB management follows a stepwise approach, including behavioral modifications, pharmacotherapy (e.g., antimuscarinics), and surgical interventions for severe cases.

Purpose of the Study:

  • To review the current understanding of OAB pathophysiology, focusing on peripheral and central nervous system contributions.
  • To discuss established and emerging treatment modalities for overactive bladder.
  • To identify existing challenges in OAB research and treatment development.

Main Methods:

  • Literature review of pathophysiological mechanisms in the urothelium, interstitial cells, and afferent neurons.
  • Analysis of the central nervous system's role in lower urinary tract function.
  • Overview of current and novel therapeutic strategies, including behavioral, pharmacological, and surgical options.

Main Results:

  • Increasing recognition of peripheral integrative interactions in OAB pathogenesis.
  • Central nervous system control adds complexity to lower urinary tract function.
  • Emerging treatments include Botulinum toxin A, beta-3 adrenergic agonists, and rho-kinase inhibitors.

Conclusions:

  • Significant theoretical and scientific hurdles remain in OAB treatment, including the lack of a disease-generating hypothesis and validated animal models.
  • The subjective nature of urgency presents a challenge for objective measurement and research.
  • Further research into underlying mechanisms is crucial for advancing OAB therapy.