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Vitamin D status in patients with Behcet's Disease
Saliha Karatay1, Kadir Yildirim, Ali Karakuzu
1Department of Physical Medicine and Rehabilitation, Ataturk University, Medical Faculty, Erzurum-Turkey. skaratay73@hotmail.com
Clinics (Sao Paulo, Brazil)
|July 27, 2011
Summary
Patients with Behcet
Area of Science:
- Rheumatology
- Endocrinology
- Nutritional Science
Background:
- Behcet's Disease is a chronic inflammatory disorder with complex etiology.
- Vitamin D plays a crucial role in immune function and inflammation modulation.
- Deficiency in vitamin D has been implicated in various autoimmune conditions.
Purpose of the Study:
- To investigate serum 25-hydroxyvitamin D levels in patients diagnosed with Behcet's Disease.
- To compare vitamin D levels between Behcet's Disease patients and healthy controls.
- To identify potential factors influencing vitamin D levels in Behcet's Disease.
Main Methods:
- A case-control study involving 32 Behcet's Disease patients and 31 healthy controls.
- Measurement of serum 25-hydroxyvitamin D, calcium, phosphate, and alkaline phosphatase.
- Assessment of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as inflammatory markers.
Main Results:
- Behcet's Disease patients exhibited significantly lower serum 25-hydroxyvitamin D levels compared to healthy controls (p<0.001).
- Inflammatory markers (ESR and CRP) were elevated in Behcet's Disease patients.
- No correlation was found between vitamin D levels and disease duration, BMI, ESR, or CRP; however, smoking, alcohol intake, and colchicine use were significant predictors.
Conclusions:
- Serum 25-hydroxyvitamin D levels are decreased in individuals with Behcet's Disease.
- Colchicine therapy, smoking, and alcohol consumption are identified as key factors affecting vitamin D status in these patients.
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