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Related Experiment Video

Updated: May 30, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Giant cell arteritis presenting as scalp necrosis.

Daniel E Maidana1, Silvia Muñoz, Xènia Acebes

  • 1Department of Ophthalmology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain. dmaidana@bellvitgehospital.cat

Thescientificworldjournal
|July 27, 2011
PubMed
Summary

Scalp necrosis in older adults can signal severe giant cell arteritis. Prompt diagnosis of this rare sign is crucial to prevent vision loss and reduce mortality.

Related Experiment Videos

Last Updated: May 30, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Area of Science:

  • Dermatology
  • Rheumatology
  • Internal Medicine

Background:

  • Scalp ulceration in elderly patients has a broad differential diagnosis.
  • Giant cell arteritis (GCA) is a systemic vasculitis affecting medium and large arteries.

Observation:

  • Scalp necrosis, a rare dermatological manifestation, was first described in association with GCA in the 1940s.
  • This sign indicates a more severe form of GCA.

Findings:

  • Patients with GCA and scalp necrosis present at a higher mean age.
  • This subgroup exhibits an increased risk of vision loss, tongue gangrene, and higher mortality rates.

Implications:

  • Early recognition of scalp necrosis in GCA is vital.
  • Prompt treatment initiation is essential to prevent irreversible complications like blindness and reduce mortality.