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Related Experiment Video

Updated: May 30, 2026

Intracranial Pharmacotherapy and Pain Assays in Rodents

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

The striatum and pain modulation.

Ana C Barceló¹, Bárbara Filippini, Jorge H Pazo

¹Facultad de Odontología, Universidad de Buenos Aires, Cátedra de Fisiología, Buenos Aires, Argentina.

Cellular and Molecular Neurobiology

|July 27, 2011

Summary

Electrical and chemical stimulation of the striatum inhibits orofacial pain by activating dopamine D(2) receptors. This pathway involves the basal ganglia and brainstem, ultimately reducing pain signals in the trigeminal nerve.

Area of Science:

Neuroscience
Pain Research
Basal Ganglia Function

Background:

The striatum plays a role in sensory processing and pain modulation.
Orofacial pain, particularly from dental pulp stimulation, is a significant clinical issue.

Purpose of the Study:

To review the striatum's sensory function in modulating orofacial pain.
To analyze the effects of striatal stimulation on pain pathways.

Main Methods:

Electrical and chemical stimulation of specific striatal sites.
Analysis of the nociceptive jaw opening reflex.
Investigation of dopamine D(2) receptor involvement.

Main Results:

Specific striatal sites were identified that inhibit nociceptive reflexes upon stimulation.

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Striatal analgesic effects are mediated by dopamine D(2) receptor activation.

The pathway involves basal ganglia indirect pathways and the medullary dorsal reticular nucleus.

Conclusions:

The striatum exerts an inhibitory influence on orofacial pain.
Dopamine D(2) receptors in the striatum are crucial for this analgesic effect.
This mechanism modulates pain transmission in the trigeminal nerve's sensory nuclei.