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Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...
Seizures l: Introduction01:20

Seizures l: Introduction

Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...

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Related Experiment Video

Updated: May 30, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

[New developments in epileptogenesis and therapeutic perspectives].

H Lerche1, A Vezzani, H Beck

  • 1Abt. Neurologie mit Schwerpunkt Epileptologie, Hertie-Institut für klinische Hirnforschung, Universitätsklinikum Tübingen, Hoppe-Seyler-Str. 3, 72076 Tübingen, Deutschland. holger.lerche@uni-tuebingen.de

Der Nervenarzt
|July 27, 2011
PubMed
Summary

Epileptogenesis, the development of epilepsy, is explored through inflammation, neuronal ion channel defects, and epigenetic changes. Understanding these mechanisms offers new therapeutic avenues for epilepsy treatment.

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A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
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A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

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Last Updated: May 30, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
10:05

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Published on: March 18, 2021

Area of Science:

  • Neuroscience
  • Pathophysiology
  • Molecular Biology

Context:

  • Epileptogenesis research focuses on understanding the underlying mechanisms driving epilepsy development.
  • Significant advancements have been made in four key areas: inflammation, neuronal intrinsic properties, epigenetics, and idiopathic epilepsy.
  • Temporal lobe epilepsy with hippocampal sclerosis (TLE with HS) serves as a key model for studying these processes.

Purpose:

  • To provide a comprehensive overview of recent progress in epileptogenesis research.
  • To highlight the roles of inflammatory processes, acquired ion channel defects, and epigenetic modifications in epilepsy generation.
  • To discuss the mechanisms of idiopathic epilepsies stemming from genetic alterations.

Summary:

  • Inflammatory processes are increasingly recognized for their role in generating TLE with HS.
  • Acquired defects in neuronal ion channels, particularly in dendrites, contribute to TLE with HS.
  • Epigenetic effects, such as promoter methylation, can alter gene expression and influence TLE with HS.
  • Idiopathic epilepsies are linked to inborn genetic alterations primarily affecting ion channels.

Impact:

  • This review consolidates current knowledge on epileptogenesis, bridging basic research with clinical applications.
  • It identifies key molecular and cellular mechanisms contributing to epilepsy.
  • The findings pave the way for novel therapeutic strategies targeting specific pathways in epilepsy treatment.