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Updated: May 30, 2026
08:51
Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling
Published on: June 25, 2015
[Enterovirus 71 induces apoptosis in a Bax dependent manner]
Zhen-min Sun1, Yan Xiao, Li-li Ren
1State Key Laboratory of Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China
Summary
Enterovirus 71 (EV71) triggers apoptosis in Rhabdomyosarcoma cells by activating Caspase proteins. This process involves a Bax conformational change, revealing EV71
Area of Science:
- Virology
- Molecular Biology
- Cellular Biology
Context:
- Enterovirus 71 (EV71) is a significant human pathogen.
- EV71 infection can lead to severe neurological diseases.
- The cellular mechanisms of EV71-induced cell death are not fully understood.
Purpose:
- To elucidate the molecular mechanisms underlying apoptosis induced by EV71 infection in Rhabdomyosarcoma (RD) cells.
Summary:
- EV71 infection was found to decrease RD cell viability.
- The study detected activation of Caspase 3, 8, and PARP, key apoptosis markers.
- EV71 infection induced Bax conformational changes, indicating its role in apoptosis initiation.
Impact:
- This research clarifies the role of the intrinsic apoptosis pathway in EV71 pathogenesis.
- Understanding EV71-induced apoptosis can inform the development of antiviral strategies.
- The findings highlight Bax conformational change as a critical event in EV71-mediated cell death.
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