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Updated: Jan 6, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Targeting STAT4 in systemic sclerosis: a promising new direction.

Jammie Barnes¹, Sandeep K Agarwal

¹Division of Rheumatology, Department of Medicine, University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA.

Expert Review of Clinical Immunology

|July 28, 2011

Summary

Inactivating the signal transducer and activator of transcription 4 (STAT4) reduces inflammation-driven fibrosis in systemic sclerosis models. This finding highlights STAT4

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Area of Science:

Immunology
Rheumatology
Dermatology

Background:

Signal transducer and activator of transcription 4 (STAT4) is a known genetic risk factor for autoimmune diseases.
STAT4 influences T-helper 1 (Th1) cell development and cell-mediated immunity.
The specific role of STAT4 in dermal fibrosis development in systemic sclerosis remains unclear.

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