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Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol
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Tryptophan hydroxylase: a target for neuroendocrine disruption

Saydur Rahman1, Izhar A Khan, Peter Thomas

  • 1Marine Science Institute, University of Texas at Austin, Port Aransas, Texas 78373, USA.

Journal of Toxicology and Environmental Health. Part B, Critical Reviews
|July 28, 2011
PubMed
Summary

Environmental stressors like hypoxia and Aroclor 1254 disrupt fish reproduction by inhibiting tryptophan hydroxylase (TPH), the key enzyme for serotonin (5-HT) synthesis. Restoring 5-HT levels or using antioxidants can reverse these effects.

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