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[Screening for colorectal neoplasms].

A Shani1, P Rozen, A Fink

  • 1Oncology Unit, Kaplan Hospital, Rehovot.

Harefuah
|January 15, 1990
PubMed
Summary
This summary is machine-generated.

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The leukocyte adherence inhibition (LAI) test showed limited efficacy for early colorectal neoplasm detection compared to the Hemoccult test. While positive in high-risk individuals, LAI had a lower predictive value for neoplasms.

Area of Science:

  • Oncology
  • Gastroenterology
  • Immunology

Background:

  • Colorectal neoplasms pose a significant health burden.
  • Early detection is crucial for improving patient outcomes.
  • Identifying effective screening methods for high-risk groups is essential.

Purpose of the Study:

  • To evaluate the efficacy of the leukocyte adherence inhibition (LAI) test for early detection of colorectal neoplasms.
  • To compare the LAI test's performance against the fecal occult blood (Hemoccult) test and endoscopic procedures.
  • To assess the LAI test's utility as a risk marker in individuals at high risk for colorectal cancer.

Main Methods:

  • Screening of high-risk individuals including first-degree relatives of cancer patients, patients with a history of colorectal adenoma/carcinoma, and those with a history of breast/gynecological cancer or inflammatory bowel disease.

Related Experiment Videos

  • Comparison of LAI test results with Hemoccult test results and findings from sigmoidoscopy or colonoscopy.
  • Inclusion of a control group of normal volunteers for comparative analysis.

    • Main Results:

    • Out of 782 fully screened individuals, 121 (15.5%) had adenomas and 5 (0.6%) had invasive cancer.
    • The LAI test was positive in 21% of high-risk individuals and 7.5% of controls.
    • The Hemoccult test was positive in 4.8% of individuals, with neoplasms found in one-third of those positive, yielding a 33% predictive value compared to 16% for the LAI test.

    Conclusions:

    • The studied groups represented individuals genuinely at high risk for colorectal neoplasms.
    • The LAI test demonstrated insufficient sensitivity for detecting benign adenomas but may serve as an additional risk marker.
    • Further long-term follow-up of high-risk individuals with positive LAI tests is warranted to identify a truly high-risk subgroup.