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Updated: May 30, 2026

In Vitro Characterization of the Electrophysiological Properties of Colonic Afferent Fibers in Rats

In Vitro Characterization of the Electrophysiological Properties of Colonic Afferent Fibers in Rats

Published on: September 27, 2017

In vitro electrical activity of the equine pelvic flexure.

C Fintl¹, G T Pearson, I G Mayhew

¹Norwegian School of Veterinary Science, Department of Companion Animal Clinical Sciences, Norway Gastrointestinal Motility and Disease Laboratory, Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK. constanze.fintl@nvh.no

Equine Veterinary Journal. Supplement

|July 28, 2011

Summary

Intracellular recordings revealed slow wave activity in equine colon smooth muscle. Nifedipine, an L-type Ca(2+) channel blocker, abolished this activity, suggesting unique ionic mechanisms in equine intestinal motility.

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Area of Science:

Veterinary Physiology
Gastrointestinal Physiology
Electrophysiology

Background:

Intestinal motility relies on interstitial cells of Cajal (ICC) generating slow waves.
Slow waves are crucial for smooth muscle contractions, but not previously documented in equine colons.
Understanding equine colon motility is vital for equine health.

Purpose of the Study:

To characterize the in vitro myoelectrical activity of the equine pelvic flexure.
To investigate the ionic basis of slow wave activity in equine colon smooth muscle.

Main Methods:

Intracellular recordings from equine pelvic flexure smooth muscle.
Superfusion of tissue with Krebs solution.
Pharmacological assessment using nifedipine (L-type Ca(2+) channel blocker) and tetrodotoxin (Na(+) channel blocker).

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Main Results:

Electrical events resembling slow waves were recorded in 10 out of 14 horses.
Nifedipine completely abolished all recorded electrical activity.
Tetrodotoxin had no discernible effect on the electrical activity.

Conclusions:

The findings suggest that L-type Ca(2+) channels play a critical role in equine colon slow wave generation.
Blockade by nifedipine indicates potential differences in ionic mechanisms compared to other species.
Further research is warranted to fully elucidate the ionic basis of equine intestinal slow waves.