Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The performance of small sample correction methods for controlling type I error when analyzing parallel cluster randomized trials: a systematic review of simulation studies.

Journal of clinical epidemiology·2025
Same author

Sample size determination for external pilot cluster randomised trials with binary feasibility outcomes: a tutorial.

Pilot and feasibility studies·2023
Same author

Antenatal preventative pelvic floor muscle exercise intervention led by midwives to reduce postnatal urinary incontinence (APPEAL): protocol for a feasibility and pilot cluster randomised controlled trial.

Pilot and feasibility studies·2022
Same author

Knowledge translation of prediction rules: methods to help health professionals understand their trade-offs.

Diagnostic and prognostic research·2021
Same author

Placental growth factor in assessment of women with suspected pre-eclampsia to reduce maternal morbidity: a stepped wedge cluster randomised control trial (PARROT Ireland).

BMJ (Clinical research ed.)·2021
Same author

Interim data monitoring in cluster randomised trials: Practical issues and a case study.

Clinical trials (London, England)·2021

Related Experiment Video

Updated: May 30, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
14:19

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

Fetal growth and birthweight standards as screening tools: methods for evaluating performance.

K Hemming1, S Bonellie, J L Hutton

  • 1Department of Public Health, University of Birmingham, UK. k.hemming@bham.ac.uk

BJOG : an International Journal of Obstetrics and Gynaecology
|July 28, 2011
PubMed
Summary

Evaluating fetal growth and birthweight standards requires different approaches for antenatal care versus epidemiology. Fetal growth standards are more sensitive for detecting stillbirth risks in clinical settings.

More Related Videos

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Related Experiment Videos

Last Updated: May 30, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
14:19

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction

Published on: June 29, 2013

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Area of Science:

  • Perinatal epidemiology
  • Obstetric clinical practice
  • Biostatistics

Background:

  • Accurate fetal growth assessment is crucial for both clinical management and epidemiological research.
  • Existing standards for fetal growth and birthweight have varying utility depending on their application.
  • Population-based data are essential for establishing reliable growth and birthweight benchmarks.

Purpose of the Study:

  • To compare the performance of fetal growth standards and population-based birthweight standards.
  • To evaluate these standards for distinct applications: antenatal care and epidemiological studies.
  • To determine the optimal method for assessing fetal well-being and population health.

Main Methods:

  • A population-based cohort study utilizing routinely collected data from Scotland.
  • Inclusion of 540,849 singletons born after 24 weeks gestation between 1980 and 2003.
  • Comparison of standards using measures of screening and diagnostic performance (sensitivity, specificity, PPV, NPV) for stillbirth risk and rates.

Main Results:

  • For antenatal care, fetal growth standards demonstrate higher sensitivity (30-43%) in detecting stillbirth risks compared to birthweight standards (29%).
  • Positive predictive values for stillbirth risk are low (~1%) across gestations for both standards.
  • For epidemiology, population birthweight standards show higher sensitivity and specificity for preterm births, but this advantage diminishes for term births.

Conclusions:

  • The choice of standard for evaluating fetal growth and birthweight is dependent on the intended use.
  • Fetal growth standards are recommended for antenatal care due to better stillbirth risk detection.
  • Different evaluation metrics are necessary for epidemiological investigations versus clinical applications.