Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Heart Failure Drugs: Diuretics

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...

Renal Failure: Dose Adjustments

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

Heart Failure VI: Adjunct Therapies

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.

Chronic Kidney Disease IV: Nursing Management

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...

Heart Failure II: Pathophysiology

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cancer as a Hidden Catalyst: Rethinking Postoperative Atrial Fibrillation After Cardiac Surgery.

Journal of clinical medicine·2026

Same author

Pulmonary Arterial Pressure Monitoring of the Pulmonary Hemodynamics With Vericiguat in Heart Failure With Reduced Ejection Fraction.

American journal of therapeutics·2026

Same author

Long-Term Prognostic Value in Nuclear Cardiology: Expert Scoring Combined with Automated Measurements vs. Angiographic Score.

Journal of imaging·2026

Same author

From Small Cavities to Big Gains: Phosphodiesterase 5 Inhibitors in LVAD Care.

JACC. Heart failure·2026

Same author

Regional Disparities and Unmet Needs in Long-Term Durable Left Ventricular Assist Device Support Across Europe.

Artificial organs·2026

Same author

Cardiac Surgery and Postoperative Atrial Fibrillation: The Role of Cancer.

Medicina (Kaunas, Lithuania)·2025

Same journal

Serum cystatin C as a biomarker of cardiac diastolic dysfunction in patients with cardiac disease and preserved ejection fraction.

Congestive heart failure (Greenwich, Conn.)·2013

Same journal

Thiamine supplementation for the treatment of heart failure: a review of the literature.

Congestive heart failure (Greenwich, Conn.)·2013

Same journal

Preload reserve is restored in patients with decompensated chronic heart failure who respond to treatment.

Congestive heart failure (Greenwich, Conn.)·2013

Same journal

Decreased readmissions and improved quality of care with the use of an inexpensive checklist in heart failure.

Congestive heart failure (Greenwich, Conn.)·2013

Same journal

Catheter ablation of atrial flutter in patients with left ventricular assist device improves symptoms of right heart failure.

Congestive heart failure (Greenwich, Conn.)·2013

Same journal

Prognosis of morbid obesity patients with advanced heart failure.

Congestive heart failure (Greenwich, Conn.)·2013

See all related articles

Search research articles

Related Experiment Video

Updated: May 30, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Renal function in advanced heart failure.

Gregory Giamouzis¹, Javed Butler, Filippos Triposkiadis

¹Department of Cardiology, Larissa University Hospital, Greece.

Congestive Heart Failure (Greenwich, Conn.)

|July 28, 2011

Summary

This summary is machine-generated.

Advanced heart failure (HF) patients face poor prognoses, with renal dysfunction worsening outcomes. Novel biomarkers may improve early identification of at-risk patients, addressing limitations of current renal function tests.

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Related Experiment Videos

Last Updated: May 30, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Area of Science:

Nephrology
Cardiology
Internal Medicine

Background:

Advanced heart failure (HF) carries a grave prognosis despite therapeutic advances.
Renal dysfunction is a frequent comorbidity in HF, significantly associated with adverse outcomes.
Intrinsic renal disease and inflammation in HF render kidneys vulnerable to hemodynamic compromise and congestion.

Purpose of the Study:

To review the multifaceted causes of renal dysfunction in advanced heart failure.
To discuss current treatment strategies for congestion relief and their impact on renal function.
To highlight the limitations of conventional renal function parameters and the potential of novel biomarkers.

Main Methods:

Literature review of studies on heart failure, renal dysfunction, and treatment strategies.
Analysis of the interplay between cardiac function, renal hemodynamics, and inflammation.
Evaluation of current and emerging diagnostic tools for renal assessment in HF.

Main Results:

Congestion relief in HF necessitates multifaceted treatment, but high-dose diuretics can exacerbate renal dysfunction.
Ultrafiltration is indicated for diuretic resistance.
Current methods for identifying "at-risk" patients for renal dysfunction are limited.

Conclusions:

Renal dysfunction is a critical factor in advanced heart failure prognosis.
Novel biomarkers for acute kidney ischemia/injury show promise for early diagnosis.
Improved identification of at-risk patients is crucial for better HF management.