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Related Experiment Video

Updated: May 30, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
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Lung function in asbestos-exposed workers, a systematic review and meta-analysis.

Dennis Wilken1, Marcial Velasco Garrido, Ulf Manuwald

  • 1Institute for Occupational and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. baur@uke.uni-hamburg.de.

Journal of Occupational Medicine and Toxicology (London, England)
|July 28, 2011
PubMed
Summary

Asbestos exposure can cause lung function impairment, even without visible changes on X-rays. This systematic review confirms asbestos-related lung function decline in workers, regardless of radiological findings.

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Area of Science:

  • Occupational Health
  • Pulmonary Medicine
  • Environmental Health

Background:

  • Controversy exists regarding asbestos exposure and lung function impairment without radiological abnormalities.
  • Systematic review and meta-analysis to assess asbestos-related lung function changes independently of radiological findings.

Purpose of the Study:

  • To determine if asbestos exposure is linked to reduced lung function parameters.
  • To evaluate lung function impairment in asbestos-exposed workers, irrespective of radiographic evidence.

Main Methods:

  • Systematic review and meta-analysis of studies indexed in MEDLINE up to April 2010.
  • Inclusion of studies assessing lung function parameters (VC, FEV1, FEV1/VC) in asbestos-exposed workers.
  • Stratification of subjects based on radiological findings and pooling of estimates.

Main Results:

  • Statistically significant reduction in vital capacity (VC), forced expiratory volume in 1 second (FEV1), and FEV1/VC ratio in 9,921 asbestos-exposed workers.
  • Lung function impairment detected even in workers without radiological changes.
  • Higher sensitivity for detecting impairment with computed tomography (CT) compared to X-rays; smoking proportion influenced impairment severity.

Conclusions:

  • Asbestos exposure is associated with both restrictive and obstructive lung function impairment.
  • A trend for functional impairment exists even without radiological evidence of parenchymal or pleural diseases.
  • Highlights the importance of assessing lung function in asbestos-exposed individuals, even in the absence of clear radiographic findings.