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Metastasis

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Related Experiment Video

Updated: May 30, 2026

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

Brain metastases.

Nicola Rosenfelder¹, Vincent Khoo

¹Royal Marsden NHS Foundation, London, UK.

BMJ Clinical Evidence

|July 28, 2011

Summary

This summary is machine-generated.

This systematic review evaluates interventions for brain metastases, including corticosteroids, surgery, and radiotherapy. It assesses the effectiveness and safety of various treatment combinations for managing these secondary brain tumors.

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Last Updated: May 30, 2026

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

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Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

Published on: January 16, 2026

Area of Science:

Neuro-oncology
Clinical Neurology
Evidence-Based Medicine

Background:

Brain metastases can originate from any primary tumor and may be single or multiple.
Symptoms range from focal neurological deficits to generalized effects, with some patients remaining asymptomatic.

Purpose of the Study:

To systematically review the effects of interventions for managing brain metastases in adults.
To evaluate the effectiveness and safety of various treatment modalities.

Main Methods:

A systematic review of literature was conducted, searching major databases up to March 2010.
Inclusion criteria encompassed systematic reviews, RCTs, and observational studies.
Harms alerts from regulatory agencies were also considered.

Main Results:

Thirty-eight studies met the inclusion criteria for the review.
A GRADE evaluation was performed to assess the quality of evidence for each intervention.

Conclusions:

The review presents data on the effectiveness and safety of interventions including corticosteroids, surgery, radiosurgery, and various radiotherapy techniques.
Combinations of treatments such as surgery plus radiotherapy were also evaluated.