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Related Concept Videos

Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Renal Drug Excretion: Effect of Urine pH, Flow Rate, and Drug pKa01:22

Renal Drug Excretion: Effect of Urine pH, Flow Rate, and Drug pKa

The pH of urine, the drug's pKa, and the urine flow rate are vital parameters for drug reabsorption and excretion. Urinary pH varies between 4.6 and 8.0 and is influenced by diet, drug intake, and the patient's pathophysiology. It affects a drug's ionization state and reabsorption. For instance, carbohydrate-rich food produces alkaline urine promoting drug excretion, while proteins and certain medications like ascorbic acid lead to acidic urine enhancing reabsorption.
The pKa of a drug,...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...

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Related Experiment Video

Updated: May 30, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

The relationship between kidney function and angiographically-derived SYNTAX score.

Li-qiu Yan1, Li-jun Guo, Fu-chun Zhang

  • 1Department of Cardiology, Peking University Third Hospital, Beijing, China.

The Canadian Journal of Cardiology
|July 28, 2011
PubMed
Summary
This summary is machine-generated.

Kidney function independently predicts SYNTAX score in coronary artery disease patients. This finding helps explain the higher cardiovascular disease risk and mortality observed in patients with impaired kidney function.

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Last Updated: May 30, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches
06:51

Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches

Published on: September 5, 2025

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Statistics

Background:

  • Chronic kidney disease (CKD) is common in coronary artery disease (CAD) patients.
  • CKD independently predicts adverse cardiovascular disease (CVD) and mortality in acute coronary syndromes.
  • The SYNTAX score (SXscore) predicts outcomes after percutaneous coronary intervention, but its association with kidney function is unknown.

Purpose of the Study:

  • To investigate the association between kidney function and the SYNTAX score in patients with established CAD.

Main Methods:

  • Retrospective analysis of 2262 patients with CAD undergoing coronary angiography.
  • Collected data on estimated glomerular filtration rate (eGFR) and SXscore.
  • Used ordinal logistic regression and correlation analyses to assess the association between eGFR and SXscore.

Main Results:

  • Patients with renal dysfunction were older, more often female, and had higher rates of hypertension and diabetes.
  • A significant inverse correlation was found between eGFR and SXscore (unadjusted r=-0.125, P<0.001; adjusted r=-0.075, P=0.019).
  • Age, gender, diabetes, and eGFR were independent predictors of SXscore.

Conclusions:

  • Kidney function is an independent predictor of SXscore in patients with established CAD.
  • This association may explain the increased CVD risk and mortality in patients with renal dysfunction.
  • Further prospective multicenter studies are recommended to validate these findings.