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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

The relationship between kidney function and angiographically-derived SYNTAX score

Li-qiu Yan1, Li-jun Guo, Fu-chun Zhang

  • 1Department of Cardiology, Peking University Third Hospital, Beijing, China.

The Canadian Journal of Cardiology
|July 28, 2011
PubMed

Insights

Kidney function independently predicts SYNTAX score in coronary artery disease patients. This finding helps explain the higher cardiovascular disease risk and mortality observed in patients with impaired kidney function.

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Statistics

Background:

  • Chronic kidney disease (CKD) is common in coronary artery disease (CAD) patients.
  • CKD independently predicts adverse cardiovascular disease (CVD) and mortality in acute coronary syndromes.
  • The SYNTAX score (SXscore) predicts outcomes after percutaneous coronary intervention, but its association with kidney function is unknown.

Purpose of the Study:

  • To investigate the association between kidney function and the SYNTAX score in patients with established CAD.

Main Methods:

  • Retrospective analysis of 2262 patients with CAD undergoing coronary angiography.
  • Collected data on estimated glomerular filtration rate (eGFR) and SXscore.
  • Used ordinal logistic regression and correlation analyses to assess the association between eGFR and SXscore.

Main Results:

  • Patients with renal dysfunction were older, more often female, and had higher rates of hypertension and diabetes.
  • A significant inverse correlation was found between eGFR and SXscore (unadjusted r=-0.125, P<0.001; adjusted r=-0.075, P=0.019).
  • Age, gender, diabetes, and eGFR were independent predictors of SXscore.

Conclusions:

  • Kidney function is an independent predictor of SXscore in patients with established CAD.
  • This association may explain the increased CVD risk and mortality in patients with renal dysfunction.
  • Further prospective multicenter studies are recommended to validate these findings.
Abstract

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