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Orthopedic management of mucopolysaccharide disease
1Seattle Children's Hospital, Department of Orthopedic Surgery, Seattle, WA, USA University of Washington, Department of Orthopedics and Sports Medicine, Seattle, WA, USA.
Abstract:
With advances in the treatment of the mucopolysaccharidosis (MPS) disorders, musculoskeletal problems are increasingly becoming a focus of care for these patients. This review discusses the current understanding of the pathophysiology of musculoskeletal disease in MPS and its orthopedic management. Deformities of the spine, hips and extremities are common and often functionally limiting. Carpal tunnel syndrome and flexor tendon triggering are common. Surgical intervention is often required to optimize long-term function.
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