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HIV-1-related thrombocytopenia

S Karpatkin1

  • 1New York University Medical School, Department of Medicine, New York.

Hematology/Oncology Clinics of North America
|February 1, 1990
PubMed

Immunologic thrombocytopenia has recently been described in HIV-1 seropositive patients: homosexuals, narcotic addicts, hemophiliacs, and heterosexual partners of HIV-1 infected patients. All patients have markedly elevated platelet-bound IgG and C3C4 as well as circulating immune complexes. The immune complexes of homosexuals and narcotic addicts contain anti-F(ab') against anti-HIV-1 antibody. These are present in the serum and on the platelets, and could be responsible for the thrombocytopenia.

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