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Inflammatory regulation of valvular remodeling: the good(?), the bad, and the ugly

Gretchen J Mahler1, Jonathan T Butcher

  • 1Department of Biomedical Engineering, Cornell University, 304 Weill Hall, Ithaca, NY 14853, USA.

International Journal of Inflammation
|July 28, 2011
PubMed

Insights

Inflammation

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Regenerative Medicine

Background:

  • Heart valve disease affects all demographics, with recent advances clarifying cell biology but leaving microenvironment interactions unknown.
  • Inflammatory signaling is implicated throughout heart valve life cycles, but its precise role in adaptation versus pathology remains unclear.

Purpose of the Study:

  • To summarize current knowledge on inflammatory mediation of heart valve remodeling.
  • To identify key research questions for future investigation in this area.

Main Methods:

  • Review of recent scientific literature on heart valve disease and inflammation.
  • Analysis of studies investigating inflammatory signaling in heart valve remodeling.

Main Results:

  • Inflammation is present at all stages of heart valve life.
  • Evidence suggests inflammation mediates both pathological valve destruction and potentially adaptive remodeling.

Conclusions:

  • Inflammatory signaling's role in heart valve remodeling is complex and not fully understood.
  • Further research is needed to elucidate the mechanisms of inflammatory signaling for potential therapeutic applications in regenerative medicine for heart valve disease.

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