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Murine Bilateral Renal Lymphadenectomy
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Published on: December 30, 2025

[Infectious lymphadenitis].

T Rüdiger1, E Geissinger

  • 1Pathologisches Institut, Städtisches Klinikum Karlsruhe, Moltkestr. 90, 76133, Karlsruhe, Deutschland. thomas.ruediger@klinikum-karlsruhe.de

Der Pathologe
|July 28, 2011
PubMed
Summary
This summary is machine-generated.

Infectious lymphadenitis, an infection of lymph node tissue, presents diagnostic challenges, often mimicking malignant lymphomas. Understanding its distinct morphological reactions is key for accurate diagnosis and differentiating it from neoplastic conditions.

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Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species
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Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species

Published on: May 19, 2018

Area of Science:

  • Pathology
  • Immunology
  • Infectious Diseases

Context:

  • Infectious lymphadenitis requires differentiation from malignant lymphomas due to overlapping clinical and morphological features.
  • Lymph node biopsies are crucial for diagnosing infectious lymphadenitis and excluding neoplastic diseases.
  • The limited repertoire of lymph nodes reacting to stimuli necessitates careful diagnostic evaluation.

Purpose:

  • To elucidate the distinct morphological reactions of infectious lymphadenitis.
  • To aid in the differential diagnosis between infectious lymphadenitis and malignant lymphomas.
  • To provide a morphological basis for identifying infectious causes of lymphadenopathy.

Summary:

  • Infectious lymphadenitis is morphologically defined as an infection of lymph node tissue, distinct from physiological hyperplasia.
  • Viral infections like HIV-associated lymphadenopathy and infectious mononucleosis elicit specific reactions (follicular and cytotoxic T-cell, respectively).
  • Most bacterial and other infections induce a histiocytic reaction, manifesting as epithelioid cell clusters, abscesses, or necrotizing granulomata.

Impact:

  • Improved diagnostic accuracy for lymphadenopathy, reducing misdiagnosis of malignant lymphomas.
  • Enhanced understanding of lymph node responses to various pathogens.
  • Guidance for pathologists in identifying infectious etiologies in lymph node biopsies.