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Related Concept Videos

Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...

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Differential phytate utilization in Candida species.

Paul Wai-Kei Tsang1

  • 1Oral BioSciences, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, Sai Ying Pun, Hong Kong, China. pwktsang@hku.hk

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|July 28, 2011
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Summary
This summary is machine-generated.

This study reveals varying phytase enzyme activity across Candida species, with some showing higher activity in low-phosphate conditions. This fungal phytase activity may aid survival in the human gut.

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Area of Science:

  • Microbiology
  • Enzymology
  • Mycology

Background:

  • Phytase enzymes are crucial for breaking down phytic acid, a major phosphorus storage form in plants.
  • Understanding phytase activity in fungi like Candida is important for their ecological roles and potential biotechnological applications.
  • Candida species are known human commensals and opportunistic pathogens, making their enzymatic activities relevant to host interactions.

Purpose of the Study:

  • To evaluate and characterize phytase activity in various Candida species.
  • To investigate the influence of environmental factors like phosphate availability, pH, and temperature on fungal phytase activity.
  • To determine if phytase activity differs between and within Candida species.

Main Methods:

  • An agar plate assay using calcium phytate as the sole phosphorus source was employed.
  • 113 Candida isolates from eight different species were screened for phytase activity.
  • Phytase activity was further characterized under varying phosphate concentrations, pH levels, and incubation temperatures.

Main Results:

  • Differential phytase activity was observed among and within Candida species.
  • Certain species (C. guilliermondii, C. krusei, C. parapsilosis, C. tropicalis) exhibited elevated phytase activity in phosphate-free media.
  • Optimal phytase activity was generally found at acidic pH and temperatures between 55-65°C.

Conclusions:

  • This study provides the first evidence of differential phytase activities across Candida species.
  • Fungal phytase activity may play a role in the survival and proliferation of Candida in nutrient-limited environments like the human gastrointestinal tract.