Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic ulcerative stomatitis associated with a specific immunologic marker.

W M Jaremko1, E H Beutner, V Kumar

  • 1Department of Dermatology, Wilford Hall U.S. Air Force Medical Center, Lackland Air Force Base, Texas.

Journal of the American Academy of Dermatology
|February 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum: Periodontal Soft Tissue Root Coverage Procedures: Practical Applications From the AAP Regeneration Workshop (Clinical Advances in Periodontics 2015;5:2-10).

Clinical advances in periodontics·2020
Same author

Loss of Discoidin Domain Receptor 1 Predisposes Mice to Periodontal Breakdown.

Journal of dental research·2019
Same author

Oncologic doses of zoledronic acid induce site specific suppression of bone modelling in rice rats.

Orthodontics & craniofacial research·2017
Same author

Gingival crevicular fluid tissue/blood vessel-type plasminogen activator and plasminogen activator inhibitor-2 levels in patients with rheumatoid arthritis: effects of nonsurgical periodontal therapy.

Journal of periodontal research·2016
Same author

The effects of periodontal therapy on gingival crevicular fluid matrix metalloproteinase-8, interleukin-6 and prostaglandin E2 levels in patients with rheumatoid arthritis.

Journal of periodontal research·2015
Same author

Fourier transform Infrared spectroscopic characterization of mineralizing type I collagen enzymatic trivalent cross-links.

Calcified tissue international·2014

Chronic ulcerative stomatitis in elderly women presents with persistent oral sores. Hydroxychloroquine shows promise for treatment, alongside specific autoantibodies as disease markers.

Area of Science:

  • Oral Medicine
  • Immunodermatology
  • Autoimmune Diseases

Background:

  • Chronic oral ulcerations can significantly impact quality of life.
  • Distinguishing between various oral mucosal diseases is clinically challenging.
  • Autoimmune processes are implicated in several chronic oral conditions.

Purpose of the Study:

  • To describe a specific cohort of elderly women with chronic oral ulcerations.
  • To investigate the clinical, histopathologic, and immunologic features of this condition.
  • To identify potential diagnostic markers and effective treatment strategies.

Main Methods:

  • Clinical case series of four elderly women with chronic oral lesions.
  • Detailed description of lesion characteristics (location, morphology).

Related Experiment Videos

  • Histopathologic examination of biopsy specimens.
  • Serologic testing for antinuclear antibodies (ANA), including stratified epithelium-specific ANA.

    • Main Results:

    • Lesions were chronic, erosive/ulcerative, affecting gingival, buccal, and lingual mucosa, sometimes presenting as desquamative gingivitis.
    • Histopathology was nondiagnostic for a specific etiology.
    • Lesions were refractory to conventional corticosteroid therapy.
    • In vivo and in vitro detection of stratified epithelium-specific antinuclear antibodies was a consistent finding.

    Conclusions:

    • A distinct oral mucosal disease, termed chronic ulcerative stomatitis associated with stratified epithelium-specific antinuclear antibody, is identified.
    • Stratified epithelium-specific antinuclear antibodies serve as valuable diagnostic markers.
    • Hydroxychloroquine demonstrates potential as an effective therapeutic agent for this condition.