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Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...

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Updated: May 30, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

[Testosterone and bone: indications and limitations].

Delphine Stoll1, Jardena J Puder, Olivier Lamy

  • 1Centre des maladies osseuses, CHUV, Lausanne. Delphine.Stoll@chuv.ch

Revue Medicale Suisse
|July 29, 2011
PubMed
Summary
This summary is machine-generated.

Testosterone therapy may improve bone mineral density in men with hypogonadism. However, its effect on fracture risk in older men requires further investigation, with specific treatment recommendations for low testosterone levels.

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Area of Science:

  • Endocrinology
  • Geriatrics
  • Bone Metabolism

Context:

  • Osteoporosis incidence rises with age, particularly in men.
  • Hypogonadism, characterized by low sex steroid levels, is a significant risk factor for osteoporosis.
  • Low testosterone levels are linked to reduced bone mineral density and increased fracture prevalence.

Purpose:

  • To review the current understanding of testosterone therapy's effects on bone health in men.
  • To highlight the correlation between sex steroid levels, bone mineral density, and fracture prevalence.
  • To establish treatment guidelines for hypogonadism in older men.

Summary:

  • Testosterone therapy generally improves bone mineral density in hypogonadal men.
  • Data on the impact of testosterone therapy on fracture incidence in men is lacking.
  • Recommendations for treating hypogonadism in older men involve specific morning testosterone level thresholds (< 8 nmol/l or < 6.9 nmol/l) and absence of contraindications.

Impact:

  • Informs clinical practice regarding testosterone replacement therapy for bone health in aging men.
  • Identifies a critical gap in research concerning fracture risk reduction with testosterone therapy.
  • Provides evidence-based criteria for diagnosing and managing hypogonadism in the elderly male population.