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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

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Related Experiment Video

Updated: May 30, 2026

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

Stem cell therapy for erectile dysfunction: a critical review.

Ching-Shwun Lin1, Zhong-Cheng Xin, Zhong Wang

  • 1Department of Urology, School of Medicine, University of California, San Francisco, California 94143-0738, USA. clin@urology.ucsf.edu

Stem Cells and Development
|July 29, 2011
PubMed
Summary
This summary is machine-generated.

Stem cell therapy shows promise for erectile dysfunction (ED), particularly for cavernous nerve (CN) injury and diabetes. However, the exact mechanisms, including cell differentiation and systemic effects, require further research.

Related Experiment Videos

Last Updated: May 30, 2026

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

Area of Science:

  • Regenerative Medicine
  • Urology
  • Cell Biology

Background:

  • Erectile dysfunction (ED) significantly impacts quality of life.
  • Current treatments are often ineffective for ED caused by cavernous nerve (CN) injury or diabetes mellitus.
  • Stem cell (SC) therapy is being investigated as a potential treatment for these ED types.

Purpose of the Study:

  • To review existing studies on stem cell (SC) therapy for erectile dysfunction (ED) in animal models.
  • To analyze the methods used for SC tracking, transplantation, and functional/histological assessment.
  • To discuss the current understanding of SC behavior and therapeutic mechanisms in ED.

Main Methods:

  • Review of 16 studies using rat models for ED.
  • Analysis of SC sources (bone marrow, adipose, skeletal muscle) and tracking methods (e.g., fluorescent proteins, nucleoside analogs).
  • Evaluation of intracavernous (IC) injection as the sole transplantation method and functional assessments via IC pressure measurements.

Main Results:

  • Favorable outcomes reported in all reviewed studies.
  • Controversy exists regarding SC differentiation into specific cell lineages.
  • Evidence suggests IC-injected SCs may rapidly exit the penis and home to bone marrow, potentially explaining systemic effects.

Conclusions:

  • Stem cell therapy demonstrates potential for treating ED, especially in cases related to CN injury and diabetes.
  • The therapeutic effects may be mediated by paracrine mechanisms rather than direct differentiation.
  • Further investigation is needed to clarify SC homing, differentiation, and the underlying mechanisms of action in ED treatment.