Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Two-Compartment Open Model: Overview

Two-Compartment Open Model: Overview

Multicompartmental models are crucial tools in pharmacokinetics, providing a framework to understand how drugs move within the body. The two-compartment model is a crucial subtype, segmenting the body into central and peripheral compartments. The central compartment represents areas with high blood flow, such as plasma and highly perfused organs like the kidneys and liver, while the peripheral compartment signifies tissues with lower blood flow, like adipose tissue and muscle tissue.
The...

Compartment Models: Two-Compartment Model

Compartment Models: Two-Compartment Model

The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Annals of work exposures and health performance, 2025.

Annals of work exposures and health·2026

Same author

Attitudes of fire service personnel toward respiratory protection in wildland firefighting.

Annals of work exposures and health·2025

Same author

Introduction to the Australian Institute of Occupational Hygienists 2024 conference special issue.

Annals of work exposures and health·2025

Same author

Continuous publication of Annals of Work Exposures and Health.

Annals of work exposures and health·2025

Same author

Annals of Work Exposures and Health Performance, 2024.

Annals of work exposures and health·2025

Same author

Integrating Power Into Research, Outreach, and Practice to Make the Most of the Next Decade of the Total Worker Health ® Program.

Journal of occupational and environmental medicine·2025

Search research articles

Related Experiment Video

Updated: May 30, 2026

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing

Published on: May 13, 2020

Comparing two-zone models of dust exposure.

Rachael M Jones¹, Catherine E Simmons, Fred W Boelter

¹ENVIRON International Corporation, Chicago, Illinois 60606, USA. rmjones@environcorp.com

Journal of Occupational and Environmental Hygiene

|July 29, 2011

Summary

This summary is machine-generated.

This study evaluated a mechanistic two-zone model for predicting dust concentrations during drywall sanding. While the model showed promise, its accuracy varied, suggesting limitations in certain application contexts.

More Related Videos

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

Published on: February 12, 2015

Related Experiment Videos

Last Updated: May 30, 2026

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing

Published on: May 13, 2020

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Evaluating Regional Pulmonary Deposition using Patient-Specific 3D Printed Lung Models

Published on: November 11, 2020

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

Published on: February 12, 2015

Area of Science:

Occupational hygiene
Environmental modeling
Industrial ventilation

Background:

Mathematical models are crucial for predicting workplace exposures, but their application can be complex.
Previous work established a semi-empirical two-zone model for estimating time-weighted average (TWA) dust concentrations (Ctwa) from drywall joint compound sanding.

Purpose of the Study:

To fit and evaluate a mechanistic two-zone model for predicting dust Ctwa during drywall sanding.
To compare the performance of the mechanistic model against a semi-empirical model and field measurements.

Main Methods:

A mechanistic two-zone model's emission rate and random air speed variables were fitted to testing data.
The fitted model was applied and evaluated using data from two distinct field studies.
Model predictions were compared with measured respirable dust Ctwa and predictions from a semi-empirical model.

Main Results:

Fitted model parameters (emission rate, random air speed) were sensitive to near-field size and fitting objective functions, but Ctwa predictions remained largely unaffected.
At Site A, the mechanistic model generally predicted lower Ctwa than the semi-empirical model and measurements, though within an acceptable range.
At Site B (10.5 m3 room), the model failed to capture spatial differences in Ctwa, predicting uniform mixing and overestimating concentrations significantly.

Conclusions:

The mechanistic two-zone model's predictions were generally lower than the semi-empirical model and field measurements at Site A.
The model's performance was inadequate at Site B, overestimating dust concentrations and not reflecting spatial variations.
Application of this mechanistic model should be restricted to scenarios where the near-field volume is considerably smaller than the far-field volume.