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Updated: May 30, 2026
Apparatus for Harvesting Tissue Microcolumns
Published on: October 25, 2018
New potential antiscarring approaches
1Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liuwei_2000@yahoo.com
Abstract:
Significant progress has been made in scar research in which an anti-transforming growth factor-β strategy has already been translated from an experimental study to a clinical trial. However, scar reduction and elimination remain an unmet medical need because of the difficulty in its treatment. The authors of this article would like to propose several new potential antiscarring approaches for scar prevention including anti-transforming growth factor-β, multifactor therapies, tissue regeneration, and tissue-engineered skin. In addition, scar remodeling is also proposed as an alternative new potential approach for scar therapy. We hope that some of these potential approaches might be translated into clinical scar therapies in the near future.
Insights
New anti-scarring strategies are proposed, including anti-transforming growth factor-β and tissue regeneration. Scar remodeling is also explored as a potential therapy to address the unmet need for effective scar reduction and elimination.
Area of Science:
- Regenerative medicine
- Wound healing research
- Biotechnology
Background:
- Scar reduction remains a significant clinical challenge despite advances.
- Anti-transforming growth factor-β strategies show promise, moving from research to clinical trials.
- Current treatments are insufficient for complete scar elimination.
Purpose of the Study:
- To propose novel therapeutic strategies for scar prevention and treatment.
- To explore advanced approaches beyond current clinical limitations.
- To identify future directions for scar therapy research.
Main Methods:
- Review and proposal of multi-faceted therapeutic strategies.
- Discussion of tissue regeneration and engineered skin applications.
- Introduction of scar remodeling as a potential therapeutic avenue.
Main Results:
- Identified anti-transforming growth factor-β as a key target.
- Proposed multifactor therapies for comprehensive scar management.
- Highlighted tissue regeneration and engineered skin for improved outcomes.
Conclusions:
- Several promising anti-scarring approaches warrant further investigation.
- Scar remodeling presents a novel therapeutic concept.
- Future clinical translation of these strategies is anticipated for better scar treatment.
