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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

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Safety and efficacy of bio-engineered, autologous dermo-epidermal skin grafts in reconstructive surgery: 1-year results of a prospective, randomized, intra-patient controlled, multicenter phase II clinical trial.

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Related Experiment Video

Updated: May 30, 2026

Generation of Self-assembled Vascularized Human Skin Equivalents
09:04

Generation of Self-assembled Vascularized Human Skin Equivalents

Published on: February 12, 2021

New dermal substitutes.

Vincent C van der Veen1, Bouke K H L Boekema, Magda M W Ulrich

  • 1Association of Dutch Burn Centers, Beverwijk, The Netherlands.

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [And] the European Tissue Repair Society
|July 29, 2011
PubMed
Summary
This summary is machine-generated.

Skin scaffolds enhance wound healing by replacing skin. Translating clinical needs into scaffold properties remains challenging, but new materials and fabrication techniques show promise for skin substitutes.

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Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

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Last Updated: May 30, 2026

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Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
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Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
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Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Skin wound healing quality can be improved using scaffolds as skin replacement materials.
  • Clinical requirements for skin substitutes are established, but translating these into scaffold properties is complex.
  • A range of natural, biological, and synthetic materials are available for skin replacement.

Purpose of the Study:

  • To review current and emerging materials and techniques for skin substitute production.
  • To discuss the challenges in defining physical and mechanobiological properties of scaffolds.
  • To explore the potential of novel materials and fabrication methods in skin regeneration.

Main Methods:

  • Review of natural and constructed biological materials.
  • Discussion of synthetic substitutes for skin replacement.
  • Exploration of advanced fabrication techniques like electrospinning and solid freeform fabrication.
  • Assessment of novel materials such as self-assembling peptides.

Main Results:

  • Various natural, biological, and synthetic materials are considered for skin substitutes.
  • Advanced techniques like electrospinning and 3D printing offer new production possibilities.
  • Self-assembling peptides represent a novel class of materials with potential applications.
  • Challenges persist in linking clinical requirements to scaffold material properties.

Conclusions:

  • Effective skin substitutes require careful consideration of material properties and fabrication methods.
  • Emerging technologies and materials hold significant potential for improving skin regeneration.
  • Bridging the gap between clinical needs and scaffold design is crucial for successful translation.