Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypertophic osteoarthropathy and clubbing: the role of prostaglandin E2.

Clinics (Sao Paulo, Brazil)·2026
Same author

Interpreting Low Alkaline Phosphatase in Fibromyalgia: The Importance of Comprehensive Clinical and Biochemical Assessment.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre·2026
Same author

PTH Analog Therapy in CKD G4-G5D: Current Evidence and Potential Role of Abaloparatide in Adynamic Bone Disease.

Journal of clinical medicine·2026
Same author

Gastroileal bypass reversal as a treatment for iatrogenic hyperparathyroidism and refractory hypocalcemia.

Endocrinologia, diabetes y nutricion·2025
Same author

Bariatric surgery: Think about osteomalacia too.

Archives of osteoporosis·2025
Same author

The Challenge of Hypophosphatasia Diagnosis in Patients with Fibromyalgia.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre·2025

Related Experiment Video

Updated: May 30, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
05:55

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

[Osteonecrosis. What is new?].

M Ángeles Martínez-Ferrer1, Pilar Peris, Nuria Guañabens

  • 1Servicio de Reumatología. Hospital Clínic i Provincial. Barcelona. España.

Reumatologia Clinica
|July 29, 2011
PubMed
Summary

Osteonecrosis, or aseptic necrosis, is a bone condition linked to various diseases. This review covers its causes, development, and current controversial treatment strategies.

Area of Science:

  • Orthopedics and Bone Diseases
  • Pathology and Cellular Biology

Context:

  • Osteonecrosis (aseptic necrosis) is a debilitating bone condition with diverse etiologies.
  • The underlying pathogenesis and optimal treatment strategies for osteonecrosis remain subjects of ongoing debate and research.

Purpose:

  • To provide a comprehensive review of the current understanding of osteonecrosis.
  • To elucidate the etiology and pathogenesis of osteonecrosis.
  • To discuss and evaluate the principal therapeutic options available for managing osteonecrosis.

Summary:

  • This review synthesizes information on the causes and pathological mechanisms of osteonecrosis.
  • It critically examines the various factors contributing to the development of aseptic necrosis.
  • The article details the spectrum of therapeutic interventions, highlighting areas of controversy.

More Related Videos

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Related Experiment Videos

Last Updated: May 30, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
05:55

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Impact:

  • This review aims to clarify the complex etiology and pathogenesis of osteonecrosis.
  • It provides valuable insights for clinicians and researchers regarding current treatment controversies.
  • Offers a foundation for future research into more effective osteonecrosis management strategies.