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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Related Experiment Video

Updated: May 30, 2026

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

[Genetics in osteoarthritis].

Mercedes Fernández-Moreno1, Ignacio Rego, Francisco J Blanco

  • 1Laboratorio de Investigación Osteoarticular y del Envejecimiento. Centro de Investigación Biomédica. Unidad de Genómica. Servicio de Reumatología. Complejo Hospitalario Universitario Juan Canalejo. A Coruña. España.

Reumatologia Clinica
|July 29, 2011
PubMed
Summary
This summary is machine-generated.

Osteoarthritis (OA) is a degenerative joint disease influenced by multiple factors, including a significant genetic component. Understanding these genetic underpinnings is crucial for future OA diagnosis and treatment.

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Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
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Last Updated: May 30, 2026

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
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Published on: March 18, 2022

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Area of Science:

  • Orthopedics and Genetics

Context:

  • Osteoarthritis (OA) is a complex degenerative joint disease characterized by cartilage deterioration.
  • The multifactorial nature of OA involves diverse interacting factors.
  • A significant genetic component in OA has been recognized since the 1950s.

Purpose:

  • To explore the genetic underpinnings of osteoarthritis.
  • To highlight the complex genetic inheritance patterns in OA.
  • To underscore the role of genetics in OA pathogenesis.

Summary:

  • Osteoarthritis pathogenesis involves complex interactions of diverse factors, with a strong genetic influence in certain forms.
  • The genetic basis of OA does not follow simple Mendelian inheritance, suggesting polygenic involvement.
  • Numerous candidate genes are implicated, indicating a complex genetic architecture for OA susceptibility.

Impact:

  • Altered gene expression levels are evident in OA.
  • Genetics is poised to become a substantial factor in future OA diagnosis and treatment strategies.
  • Further research into genetic mechanisms is essential for advancing OA management.