[Contribution of animal models to the study and treatment of systemic autoimmune disease]

Animal models of autoimmune diseases, either spontaneous or induced, have been very useful tools to investigate the mechanisms involved in the pathogenesis of human autoimmune diseases as well as in the design of new therapeutic strategies for their treatment. The development of biotechnology and molecular biology resulted in the production of transgenic animals overexpressing or lacking a given protein. As a result of this technology, a great number of animal models of human diseases have been developed in recent years. A further evolution in transgenic methodology allows the selective control of gene expression in a particular organ or tissue at desired time points during embryonic or postnatal development. In the present article the authors discuss the advantages and inconveniences of animal models and describe the most frequently employed models in the study of 4 rheumatologic syndromes with an autoimmune origin: rheumatoid arthritis, systemic lupus erythematosus, scleroderma, and spondiloarthritis.