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Updated: May 30, 2026
09:08
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
[Sarcoidosis-lymphoma syndrome]
Elisabet García Casares1, Lourdes Mateo Soria, Emma García Melchor
1Sección de Reumatología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España.
Reumatologia Clinica
|July 29, 2011
Summary
Sarcoidosis and lymphoma can coexist as sarcoidosis-lymphoma syndrome. Differentiating these conditions requires lymph node biopsy due to overlapping symptoms and non-specific tests.
Area of Science:
- Immunology
- Oncology
- Pathology
Context:
- Sarcoidosis and lymphoma can present with overlapping clinical and laboratory features.
- Distinguishing between sarcoidosis and lymphoma, or confirming their co-existence, poses a diagnostic challenge for clinicians.
- The sarcoidosis-lymphoma syndrome is an uncommon but recognized association.
Purpose:
- To highlight the diagnostic challenges in differentiating sarcoidosis from lymphoma.
- To present a case report illustrating the sarcoidosis-lymphoma syndrome.
- To discuss potential pathomechanisms involving immune system disturbances.
Summary:
- The sarcoidosis-lymphoma syndrome involves the co-occurrence of sarcoidosis and lymphoma.
- Clinical and laboratory findings are often non-specific, necessitating histopathological examination of lymphadenopathy for diagnosis.
- This syndrome may arise from immune dysregulation in sarcoidosis or in malignancy patients undergoing chemotherapy.
Impact:
- Emphasizes the critical role of anatomopathological studies in diagnosing complex cases.
- Provides insight into a rare condition that requires careful clinical and diagnostic consideration.
- Contributes to the understanding of immune system interactions in the context of sarcoidosis and malignancy.
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