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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
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Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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[Synovial sarcomas in Lugo between 2002-2006].

Manuel Bravo-Pérez1, Susana López-López, Alberto Miranda-Filloy

  • 1Servicio de Cirugía Ortopédica y Traumatología, Hospital Xeral-Calde, Lugo, España.

Reumatologia Clinica
|July 29, 2011
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Summary

This study analyzed synovial sarcoma cases in adults in Lugo, Spain. Delayed diagnosis, often presenting as a palpable mass, correlated with larger tumors and poorer prognosis, highlighting the need for increased physician awareness.

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Area of Science:

  • Oncology
  • Epidemiology
  • Pathology

Context:

  • Synovial sarcoma is a rare soft tissue sarcoma.
  • Hospital Xeral-Calde serves a population of 250,000.
  • Data collected from 2002-2006.

Purpose:

  • To determine the clinical and epidemiological characteristics of adult synovial sarcoma patients.
  • To estimate the incidence of synovial sarcoma in the Lugo region.

Summary:

  • Retrospective study of 4 adult patients diagnosed with synovial sarcoma.
  • Mean age 35, most common presentation was a lower extremity palpable mass with pain.
  • Mean diagnostic delay was 17 months, associated with larger tumor size and higher grade; one patient died.

Impact:

  • Minimum estimated annual incidence of 0.32/10(5) in adults over 18 in Lugo.
  • Increased physician awareness is crucial for early detection, especially in young patients with palpable masses.
  • Delayed diagnosis significantly worsens prognosis for synovial sarcoma.