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Nephrogenic systemic fibrosis in a patient with a p-ANCA systemic vasculitis
Eduardo Cuende1, Mikel Aldamiz, Joseba Portu
1Rheumatology Service, Hospital Príncipe de Asturias, Alcalá de Henares, Spain.
Abstract:
Nephrogenic systemic fibrosis (NSF) is a fibrosing skin condition of unknown origin. Most cases have been described in patients with acute or chronic renal failure. The cutaneous changes include firm and thickened, indurate skin plaques and papules on the extremities and trunk. Histopathology typically shows an increase in dermal fibroblast-like cells associated with mucin deposition. Previous exposition to gadolinium-based contrast agents was closely associated with its onset. We described a patient with the clinical and pathologic picture of NSF presented after an acute renal failure in the course of a perinuclear antineutrophil cytoplasmic antibodies associated systemic vasculitis.
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