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Updated: May 30, 2026

Human In-Vivo Bioassay for the Tissue-Specific Measurement of Nociceptive and Inflammatory Mediators
Published on: December 1, 2008
[TNF and cytokines and pain: Beyond the tisular inflammation]
M A Remedios Moreno Brea1, Juan Antonio Micó
1Departamento de Neurociencias, Universidad de Cádiz, CIBER de Salud Mental (CIBERSAM), Cádiz, España.
Abstract:
Numerous studies support the participation of cytokines in the transmission of pain, especially in neuropathic pain. Results obtained both from different experimental pain models as well as studies from a clinical perspective implicate diverse cytokines, especially some of a proinflammatory nature, in the physiopathology of chronic pain. Selective pharmacologic manipulation of these pathways key molecules represents and constitutes a treatment opportunity and an answer to this painful pathology which currently has a difficult solution.
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