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Updated: May 30, 2026
06:35
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
[Churg-Strauss Vasculitis. Description of 9 cases]
Emma García-Melchor1, Sonia Mínguez Blasco, Anna Moltó Revilla
1Sección de Reumatología, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España.
Reumatologia Clinica
|July 29, 2011
Summary
Churg-Strauss Syndrome (SCS) is a vasculitis affecting multiple organs, often presenting with asthma and eosinophilia. This study highlights clinical features and treatment responses in nine SCS patients, noting high ANCA positivity.
Area of Science:
- Rheumatology
- Immunology
- Pulmonology
Context:
- Churg-Strauss Syndrome (SCS), a rare necrotizing vasculitis, involves small to medium-sized vessels.
- Key features include asthma, eosinophilia, and granulomatous inflammation.
Purpose:
- To analyze the epidemiological, clinical, laboratory, and pathological characteristics of nine patients diagnosed with SCS.
- To evaluate treatment strategies and outcomes in a university referral center.
Summary:
- Nine patients (7 males, mean age 51) with SCS were retrospectively studied.
- Commonly affected organs included skin, musculoskeletal system, peripheral nervous system, and lungs.
- All patients had peripheral eosinophilia, and 66% tested positive for ANCA (p-ANCA pattern).
Impact:
- This case series provides insights into the presentation and management of SCS.
- Findings emphasize the importance of tailored treatment combining corticosteroids and immunosuppressants based on organ involvement.
- The study underscores a higher prevalence of ANCA positivity in SCS patients.
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