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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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An update in bone mineral density status in Spain: the OsteoSER study.

Archives of osteoporosis·2025
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Related Experiment Video

Updated: May 30, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

[Osteoporosis in young individuals].

Pilar Peris Bernal1

  • 1Servicio de Reumatología, Hospital Clínic, IDIBAPS, Universidad de Barcelona, Barcelona, España.

Reumatologia Clinica
|July 29, 2011
PubMed
Summary

Osteoporosis affects young individuals of both genders equally, often due to secondary causes like glucocorticoid therapy. Extensive lab tests are crucial for diagnosis, with treatment tailored to the underlying cause.

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Gerontology

Context:

  • Osteoporosis diagnosis in young individuals presents unique challenges compared to older populations.
  • Secondary causes are prevalent, accounting for nearly 50% of osteoporosis cases in this demographic.
  • Gender-specific etiologies contribute to the development of osteoporosis in younger individuals.

Purpose:

  • To highlight the prevalence and common secondary causes of osteoporosis in young individuals.
  • To emphasize the need for comprehensive laboratory evaluation to identify underlying conditions.
  • To discuss general treatment recommendations and cautious drug therapy considerations for young patients.

Summary:

  • Osteoporosis occurs with similar frequency in young males and females, frequently linked to secondary factors such as glucocorticoid use.

Related Experiment Videos

Last Updated: May 30, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

  • Idiopathic osteoporosis and conditions like hypercalciuria are also observed, necessitating thorough diagnostic workups.
  • Management involves lifestyle modifications, with pharmacotherapy requiring careful consideration, especially in women of childbearing age.

    • Impact:

    • Informs clinicians about the importance of investigating secondary causes in young osteoporosis patients.
    • Guides diagnostic strategies, emphasizing extensive laboratory testing.
    • Promotes cautious and individualized treatment approaches, particularly for young women.