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Updated: May 30, 2026

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
07:25

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis

Published on: May 4, 2017

[Certolizumab pegol]

Esmeralda Delgado Frías1, José Federico Díaz González

  • 1Servicio de Reumatología, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Islas Canarias, España.

Reumatologia Clinica
|July 29, 2011
PubMed

Certolizumab pegol is a new anti-TNF drug formed by the Fab' fragment of a humanized mouse monoclonal antibody bound to two molecules of polyethylene glycol. Certolizumab pegol recognizes and binds to human TNF-α, both in its soluble and membrane bound form, and has shown clinical efficacy in controlled trials for the treatment of RA and Crohns' disease. In this review we summarize the structural characteristics and clinical efficacy data, as well as safety data of this anti-TNF agent in patients with RA.

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